4-Methyltetrahydropyran
MTHP
CAS No. 4717-96-8
A new innovative reaction solvent "MTHP" leads to environment-friendly processes.
Features
High Hydrophobicity
MTHP can simplify the reaction process. It also reduces the environmental impact of waterwaste.
Solvency Power close to THF
MTHP can be used for various reactions.
High Stability
MTHP is stable in acids and bases and oxidizes slower in air.
-
Left: water+THF
Right: water+MTHP
Applications
- Reaction solvent (MTHP can be used in almost any reaction such as Grignard, Suzuki-coupling, metathesis, and halogenation)
- Polymerization solvent
- Extractions
- Coatings
Physical Properties
| BP (oC) | MP (oC) | Specific gravity (20oC,g/cm3) |
Viscosity (cP) | Flash point (oC) | Solubility in water (wt%) |
Water solubility (wt%) |
Azeotropic point (oC) (H2O ratio) | SP value* (cal/cm3)^0.5 | |
|---|---|---|---|---|---|---|---|---|---|
| MTHP | 105 | -92 | 0.86 | 0.78 | 6.5 | 1.5 | 1.4 | 85 (19wt%) | 9.0 |
| THF | 65 | -109 | 0.89 | 0.55 | -15 | ∞ | ∞ | 64 (6.0wt%) | 9.5 |
| 2MTHF | 80 | -136 | 0.85 | 0.60 | -11 | 14 | 4.4 | 71 (11wt%) | 8.9 |
| CPME | 106 | -140 | 0.86 | 0.55 | -1 | 1.1 | 0.3 | 83 (16wt%) | 8.4 |
| Et2O | 34.6 | -116 | 0.70 | 0.24 | -45 | 6.5 | 1.2 | 34 (1.3wt%) | 7.6 |
| 1,4-Dioxane | 101 | 12 | 1.04 | 1.30 | 11 | ∞ | ∞ | 88 (18wt%) | 10.0 |
Process improvement
MTHP can be recovered and reused due to its good separation from water. In addition, the reaction solution does not need to be concentrated or extracted during post-processing, which saves energy and reduces CO2 emissions.
Example of Process Simplification and CO2 Reduction
